Agnew Amanda M, Moorhouse Kevin, Kang Yun-Seok, Donnelly Bruce R, Pfefferle Kiel, Manning Angela X, Litsky Alan S, Herriott Rod, Abdel-Rasoul Mahmoud, Bolte John H
Injury Biomechanics Research Center, Division of Anatomy, The Ohio State University, 279 Hamilton Hall, 1645 Neil Ave, Columbus, OH, 43210, USA,
Ann Biomed Eng. 2013 Dec;41(12):2501-14. doi: 10.1007/s10439-013-0875-6. Epub 2013 Aug 2.
Traumatic injury is a major cause of death in the child population. Motor vehicle crashes account for a large portion of these deaths, and a considerable effort is put forth by the safety community to identify injury mechanisms and methods of injury prevention. However, construction of biofidelic anthropomorphic test devices and computational models for this purpose requires knowledge of bone properties that is difficult to obtain. The objective of this study is to characterize the relationship between mechanical properties and measures of skeletal development in the growing rib. Anterolateral segments of 44 ribs from 12 pediatric individuals (age range: 5 months to 9 years) were experimentally tested in three-point bending. Univariate mixed models were used to assess the predictive abilities of development-related variables (e.g., age, stature, histomorphometry, cross-sectional geometry) on mechanical variables (material and structural properties). Results show that stature, in addition to age, may be a reliable predictor of bone strength, and that histomorphometry has potential to explain bone properties and to further our understanding of fracture mechanisms. For example, percent secondary lamellar bone (%Sd.Ar) successfully predicts peak force (F P) and Young's modulus (E). Application of these findings is not restricted to injury biomechanics, but can also be referenced in forensic and anthropological contexts.
创伤性损伤是儿童群体死亡的主要原因。机动车碰撞事故在这些死亡案例中占很大比例，安全领域投入了大量精力来确定损伤机制和预防损伤的方法。然而，为此构建生物逼真的人体模型测试装置和计算模型需要难以获取的骨骼特性知识。本研究的目的是描述生长中的肋骨力学性能与骨骼发育指标之间的关系。对12名儿科个体（年龄范围：5个月至9岁）的44根肋骨的前外侧段进行了三点弯曲实验测试。使用单变量混合模型评估与发育相关的变量（如年龄、身高、组织形态计量学、横截面几何形状）对力学变量（材料和结构特性）的预测能力。结果表明，除年龄外，身高可能是骨强度的可靠预测指标，并且组织形态计量学有潜力解释骨骼特性并加深我们对骨折机制的理解。例如，次生板层骨百分比（%Sd.Ar）成功预测了峰值力（FP）和杨氏模量（E）。这些发现的应用不仅限于损伤生物力学，在法医和人类学领域也可作为参考。
