Cha Hyuk-Jin, Yim Hyungshin
Department of Life Science, Sogang University, Seoul, 120-742, Republic of Korea.
Tumour Biol. 2013 Dec;34(6):3293-302. doi: 10.1007/s13277-013-1038-y. Epub 2013 Aug 2.
Genomic instability has been considered to be one of the prominent factors for carcinogenesis and the development of a number of degenerative disorders, predominantly related to the aging. The cellular machineries involved in the maintenance of genomic integrity such as DNA repair and DNA damage responses are extensively characterized by a large number of studies. The failure of proper actions of such cellular machineries may lead to the devastating effects mostly inducing cancer or premature aging, even with no acute exogenous DNA damage stimuli. In this review, we especially focus on the pathophysiological aspects of the defective DNA damage responses in carcinogenesis and premature aging. Clear understanding the causes of carcinogenesis and age-related degenerative diseases will provide novel and efficient approaches for prevention and rational treatment of cancer and premature aging.
基因组不稳定被认为是致癌作用以及许多退行性疾病发展的主要因素之一，这些疾病主要与衰老相关。参与维持基因组完整性的细胞机制，如DNA修复和DNA损伤反应，已被大量研究广泛表征。即使没有急性外源性DNA损伤刺激，此类细胞机制的正常作用失败也可能导致毁灭性影响，主要诱发癌症或早衰。在本综述中，我们特别关注致癌作用和早衰中DNA损伤反应缺陷的病理生理学方面。清楚了解致癌作用和与年龄相关的退行性疾病的病因，将为癌症和早衰的预防及合理治疗提供新颖且有效的方法。
