Department of Nuclear Medicine, Royal North Shore Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia.
J Nucl Med. 2013 Sep;54(9):1588-96. doi: 10.2967/jnumed.113.124602. Epub 2013 Aug 1.
Planar ventilation-perfusion (V/Q) scanning is often used to investigate pulmonary embolism; however, it has well-recognized limitations. SPECT overcomes many of these through its ability to generate 3-dimensional imaging data. V/Q SPECT has higher sensitivity, specificity, and accuracy than planar imaging and a lower indeterminate rate. SPECT allows for new ways to display and analyze data, such as parametric V/Q ratio images. Compared with CT pulmonary angiography, SPECT has higher sensitivity, a lower radiation dose, fewer technically suboptimal studies, and no contrast-related complications. Any nuclear medicine department equipped with a modern hybrid scanner can now perform combined V/Q SPECT with CT (using low-dose protocols) to further enhance diagnostic accuracy. V/Q SPECT (with or without CT) has application in other pulmonary conditions and in research.
平面通气灌注（V/Q）扫描常用于研究肺栓塞，但它存在明显的局限性。SPECT 通过生成 3 维成像数据克服了这些局限性。与平面成像相比，V/Q SPECT 具有更高的敏感性、特异性和准确性，以及更低的不确定率。SPECT 允许使用新的方法来显示和分析数据，如参数 V/Q 比值图像。与 CT 肺动脉造影相比，SPECT 具有更高的敏感性、更低的辐射剂量、更少的技术不佳的研究以及无造影相关并发症。任何配备现代混合扫描仪的核医学科现在都可以使用低剂量方案进行 V/Q SPECT 与 CT 的联合检查，以进一步提高诊断准确性。V/Q SPECT（无论是否与 CT 联合使用）在其他肺部疾病和研究中都有应用。
