Ji X L, Li W H
Department of Pathology, Chinese PLA General Hospital.
Zhonghua Bing Li Xue Za Zhi. 1990 Jun;19(2):128-9.
S-100 and its subunits have subsequently been shown to be present in a wide variety of human neoplastic tissues. Three antibodies, monoclonal S-100, polyclonal S-100 and HMB-45, were used for comparison of the positive rates of different sites of melanomas. The results showed that HMB-45 was positive for those melanoma cells in epidermis and negative for those in dermis. Monoclonal S-100 was negative for melanoma cells in epidermis and positive for those in dermis. They are useful for the diagnosis of melanoma in surgical pathology.
随后发现S - 100及其亚基存在于多种人类肿瘤组织中。使用三种抗体，即单克隆S - 100、多克隆S - 100和HMB - 45，比较黑色素瘤不同部位的阳性率。结果显示，HMB - 45对表皮中的黑色素瘤细胞呈阳性，对真皮中的黑色素瘤细胞呈阴性。单克隆S - 100对表皮中的黑色素瘤细胞呈阴性，对真皮中的黑色素瘤细胞呈阳性。它们在外科病理学中对黑色素瘤的诊断很有用。
