Ordóñez N G, Ji X L, Hickey R C
Department of Pathology, U.T.M.D. Anderson Hospital, Houston, Texas 77030.
Am J Clin Pathol. 1988 Oct;90(4):385-90. doi: 10.1093/ajcp/90.4.385.
The value of HMB-45 mouse monoclonal antibody in the immunohistochemical diagnosis of melanoma was compared with that of two antibodies to S-100 protein. Tissue from 32 (91.4%) of the 35 melanomas studied reacted with HMB-45, however, none of the 98 nonmelanoma tumors stained with this antibody. In contrast, 31 (88.5%) melanomas and 24 (24.4%) of the nonmelanoma neoplasms expressed S-100 protein. These results indicated that HMB-45 monoclonal antibody has a higher specificity for melanoma cells than did S-100 protein and that, because of its reactivity in routinely processed tissues, it may be helpful in surgical pathology.
