秀丽隐杆线虫中的转化生长因子-β信号传导
TGF-β signaling in C. elegans.
作者信息
Gumienny Tina L, Savage-Dunn Cathy
机构信息
Department of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, TX 77843, USA.
出版信息
WormBook. 2013 Jul 10:1-34. doi: 10.1895/wormbook.1.22.2.
Abstract
Transforming Growth Factor-β (TGF-β) superfamily ligands regulate many aspects of cell identity, function, and survival in multicellular animals. Genes encoding five TGF-β family members are present in the genome of C. elegans. Two of the ligands, DBL-1 and DAF-7, signal through a canonical receptor-Smad signaling pathway; while a third ligand, UNC-129, interacts with a noncanonical signaling pathway. No function has yet been associated with the remaining two ligands. Here we summarize these signaling pathways and their biological functions.
摘要
转化生长因子-β（TGF-β）超家族配体调节多细胞动物细胞特性、功能和存活的许多方面。秀丽隐杆线虫基因组中存在编码五个TGF-β家族成员的基因。其中两个配体DBL-1和DAF-7通过经典的受体- Smad信号通路进行信号传导；而第三个配体UNC-129则与非经典信号通路相互作用。其余两个配体尚未发现有相关功能。在此，我们总结这些信号通路及其生物学功能。
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