Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
J Nucl Med. 2013 Aug;54(8):1171-4. doi: 10.2967/jnumed.113.126086.
The development of noninvasive imaging techniques using monoclonal antibodies (mAbs) is a quickly evolving field. Immuno-PET uses positron-emitting isotopes to track the localization of mAbs with excellent image quality. Procedures for labeling mAbs with (89)Zr or (124)I using good manufacturing procedures have been established, and therefore these radiopharmaceuticals are being investigated for clinical use. This short review will focus on immuno-PET with full mAbs using long-lived positron-emitting isotopes ((89)Zr and (124)I) over the past 5 y and discuss their progress into clinical use.
使用单克隆抗体 (mAbs) 的无创成像技术的发展是一个快速发展的领域。免疫 PET 使用正电子发射同位素来跟踪 mAbs 的定位，具有出色的图像质量。已经建立了使用良好生产规范对 mAbs 进行标记的 (89)Zr 或 (124)I 的程序，因此正在研究这些放射性药物用于临床用途。这篇简短的综述将重点介绍过去 5 年来使用长寿命正电子发射同位素 ((89)Zr 和 (124)I) 的完整 mAbs 的免疫 PET，并讨论它们在临床应用中的进展。
