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Response of CFTR-deficient mice to long-term chronic Pseudomonas aeruginosa infection and PTX3 therapy.CFTR 缺陷小鼠对长期慢性铜绿假单胞菌感染和 PTX3 治疗的反应。
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3
The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa.体液模式识别分子 PTX3 在铜绿假单胞菌引起的慢性肺部感染中的治疗潜力。
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Pseudomonas aeruginosa microevolution during cystic fibrosis lung infection establishes clones with adapted virulence.铜绿假单胞菌在囊性纤维化肺部感染期间的微观进化产生了具有适应性毒力的克隆。
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Cystic fibrosis and other respiratory diseases of impaired mucus clearance.囊性纤维化及其他黏液清除功能受损的呼吸道疾病。
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持续性囊性纤维化分离株铜绿假单胞菌RP73的全基因组序列

Complete Genome Sequence of Persistent Cystic Fibrosis Isolate Pseudomonas aeruginosa Strain RP73.

作者信息

Jeukens Julie, Boyle Brian, Bianconi Irene, Kukavica-Ibrulj Irena, Tümmler Burkhard, Bragonzi Alessandra, Levesque Roger C

机构信息

Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Quebec, Canada.

出版信息

Genome Announc. 2013 Aug 1;1(4):e00568-13. doi: 10.1128/genomeA.00568-13.

DOI:10.1128/genomeA.00568-13
PMID:23908295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3731849/
Abstract

Pseudomonas aeruginosa can establish lifelong chronic airway infections in cystic fibrosis (CF) patients. However, the genetic features associated with long-term persistence in the lung are not understood. We sequenced the genome of P. aeruginosa strain RP73, which was isolated after 16.9 years of chronic lung infection in a CF patient.

摘要

铜绿假单胞菌可在囊性纤维化（CF）患者中引发终身性慢性气道感染。然而，与在肺部长期持续存在相关的基因特征尚不清楚。我们对铜绿假单胞菌RP73菌株的基因组进行了测序，该菌株是从一名CF患者慢性肺部感染16.9年后分离得到的。