评估抗体效价与儿童确诊流感病毒感染防护之间的关联。
Estimation of the association between antibody titers and protection against confirmed influenza virus infection in children.
机构信息
School of Public Health.
出版信息
J Infect Dis. 2013 Oct 15;208(8):1320-4. doi: 10.1093/infdis/jit372. Epub 2013 Aug 1.
Abstract
Antibody titers measured by hemagglutination inhibition (HAI) correlate with protection against influenza virus infection and are used to specify criteria for vaccine licensure. In a randomized, controlled trial of seasonal influenza vaccination in 773 children aged 6-17 years, we estimated that HAI titers of 1:40 against A(H1N1)pdm09 and B(Victoria lineage) were associated with 48% (95% confidence interval [CI], 30%-62%) and 55% (95% CI, 32%-70%) protection against PCR-confirmed infection with each strain. Our analysis accounted for waning in antibody titers over time, and could be particularly useful in settings where influenza activity is delayed or prolonged relative to measurement of antibody titers.
摘要
通过血凝抑制（HAI）测量的抗体效价与预防流感病毒感染相关，并用于确定疫苗许可标准。在一项针对 773 名 6-17 岁儿童的季节性流感疫苗接种的随机对照试验中，我们估计针对 A(H1N1)pdm09 和 B（维多利亚系）的 HAI 效价为 1:40 时，与每种毒株的 PCR 确诊感染的 48%（95%置信区间 [CI]，30%-62%）和 55%（95% CI，32%-70%）的保护作用相关。我们的分析考虑了抗体效价随时间的衰减，在抗体效价的测量与流感活动的延迟或延长相关的情况下，这种分析可能特别有用。
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