Geisel School of Medicine at Dartmouth.
J Infect Dis. 2013 Nov 15;208(10):1629-33. doi: 10.1093/infdis/jit396. Epub 2013 Aug 1.
The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCG-immunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.
尚不清楚预先存在的干扰素 (IFN) γ 反应在控制人类免疫缺陷病毒 (HIV) 相关结核病中的细菌负荷中的作用。在一项针对一种实验性结核病疫苗的 III 期试验中，BCG 免疫的 HIV 感染成年人发生结核病，结果显示，对早期分泌性抗原靶 6 和结核分枝杆菌全细胞裂解物的基线 IFN-γ 反应越强，痰涂片等级的细菌负荷越低，琼脂上培养阳性的天数越少，随后的痰培养等级越低。这种关联在接受实验性疫苗的接种者中最为一致。当 HIV 相关结核病发生时，对分枝杆菌抗原预先存在的 IFN-γ 反应越强，结核分枝杆菌的细菌负荷越低。临床试验标识符。NCT0052195。
