Zhu M X
1st Affiliated Hospital, Huaxi Medical University, Chengdu.
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990 Apr;23(2):96-9, 127.
Pregnant rats were divided into four groups. The groups A, B and C were intraperitoneally injected with DPH during the 9 to 11 days of gestation in doses of 75 Mg/kg/day. The groups A and B were supplemented with a mixture of folic acid (FA) or with FA alone in the food fed during pregnancy. The results showed that DPH induced a significant decrease in the body weights and lengths of fetal rats (P less than 0.01), but induced an increase in the incidences of subcutaneous bleeding (P less than 0.05) as well as skeletal and internal malformation (P less than 0.05). The supplement of FA or a mixture of FA in the food fed during pregnancy exhibited partial preventive effects on DPH to induce teratogenicity. The effect of a mixture of FA was better than that with FA alone in reducing the incidences of internal abnormalities and agenesis of the bones of the distant phalanges and subcutaneous bleeding.
将怀孕大鼠分为四组。A、B、C组在妊娠第9至11天腹腔注射剂量为75毫克/千克/天的DPH。A组和B组在孕期所喂食物中补充叶酸（FA）混合物或仅补充FA。结果显示，DPH导致胎鼠体重和体长显著降低（P<0.01），但导致皮下出血发生率增加（P<0.05）以及骨骼和内脏畸形发生率增加（P<0.05）。孕期所喂食物中补充FA或FA混合物对DPH诱导的致畸作用有部分预防效果。在降低内脏异常、远端指骨骨骼发育不全和皮下出血的发生率方面，FA混合物的效果优于单独补充FA。
