母体联合补充叶酸和维生素B12可抑制乙醇诱导的小鼠胎儿发育毒性。
The maternal combined supplementation of folic acid and Vitamin B(12) suppresses ethanol-induced developmental toxicity in mouse fetuses.
作者信息
Xu Yajun, Li Yong, Tang Yunan, Wang Junbo, Shen Xiaoyi, Long Zhu, Zheng Xiaoying
机构信息
Department of Nutrition and Food Hygiene, Laboratory of Molecular Toxicology and Developmental Molecular Biology, School of Public Health, Peking University, Beijing 100083, China.
出版信息
Reprod Toxicol. 2006 Jul;22(1):56-61. doi: 10.1016/j.reprotox.2005.12.004. Epub 2006 Jan 24.
Maternal ethanol consumption during pregnancy can induce developmental defects in the fetus. The objective of this study was to assess whether combined supplementation of folic acid (FA) and Vitamin B(12) (VB(12)) in dams would suppress ethanol-induced developmental toxicity in CD-1 mice. Ethanol (5.0 g/kg) was given intragastrically from gestational day (GD) 6 to GD15. Vitamin supplementation groups were additionally given 60.0 mg/kg FA, 1.0 mg/kg VB(12), or 60.0 mg/kg FA+1.0 mg/kg VB(12) during GD1-16. The control group received distilled water only. Results of litter evaluation on GD18 showed that combined supplementation of FA and VB(12) ameliorated many of the adverse effects of ethanol. In contrast, the single vitamin supplementation groups showed little or no amelioration. These results suggest that combined supplementation of FA and VB(12) was more effective than each vitamin toward suppressing ethanol-induced developmental toxicity in CD-1 mice.
孕期母体摄入乙醇可导致胎儿发育缺陷。本研究的目的是评估在母鼠中联合补充叶酸（FA）和维生素B12（VB12）是否会抑制乙醇诱导的CD-1小鼠发育毒性。从妊娠第6天至第15天经胃内给予乙醇（5.0 g/kg）。在妊娠第1天至第16天，维生素补充组额外给予60.0 mg/kg FA、1.0 mg/kg VB12或60.0 mg/kg FA + 1.0 mg/kg VB12。对照组仅接受蒸馏水。在妊娠第18天进行的窝仔评估结果显示，联合补充FA和VB12改善了乙醇的许多不良反应。相比之下，单一维生素补充组几乎没有改善或没有改善。这些结果表明，联合补充FA和VB12在抑制乙醇诱导的CD-1小鼠发育毒性方面比每种维生素更有效。
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