Rowe Jacob M
Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel; Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa, Israel; and Technion, Israel Institute of Technology, Haifa, Israel.
Rambam Maimonides Med J. 2013 Jan 30;4(1):e0004. doi: 10.5041/RMMJ.10104. Print 2013 Jan.
Results of clinical studies are often contradictory in real time, and in other instances therapies may be adopted due to information from clinical studies where the data may be premature or resulting from small studies. Much of the data may have inherent selection biases, and their interpretation may be confusing and difficult. The hematological literature is full of such examples, and this review will describe some such instances in the hope of introducing both a cautionary note and encouraging more precise description of study conditions as well as an appreciation of the importance of allowing data from clinical studies to mature. Several examples will be drawn from clinical studies in lymphomas, leukemia, and bone marrow transplantation.
临床研究结果在实际中常常相互矛盾，在其他情况下，由于临床研究提供的信息（这些数据可能还不成熟或来自小规模研究），某些治疗方法可能会被采用。许多数据可能存在内在的选择偏差，对其解读可能令人困惑且困难。血液学文献中充斥着此类例子，本综述将描述一些这样的实例，以期既敲响警钟，又鼓励更精确地描述研究条件，同时让人们认识到让临床研究数据成熟的重要性。将从淋巴瘤、白血病和骨髓移植的临床研究中选取几个例子。
