亲身感受克罗恩病。
Taking Crohn's disease personally.
作者信息
Chowers Yehuda
机构信息
Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.
出版信息
Rambam Maimonides Med J. 2013 Apr 30;4(2):e0011. doi: 10.5041/RMMJ.10111. Print 2013 Apr.
Crohn's disease (CD) is a heterogeneous disorder that can involve any segment of the gastrointestinal tract. The pathogenesis of CD is unknown but is thought to involve an uncontrolled immune response triggered by an environmental factor in a genetically susceptible host. The heterogeneity of disease pathogenesis and clinical course, combined with the variable response to treatment and its associated side effects, creates an environment of complex therapeutic decisions. Despite this complexity, significant progress has been made which allows physicians to start and predict disease behavior and natural course, response to therapy, and factors associated with significant side effects. In this manuscript the data pertaining to these variables including clinical, endoscopic and the various biological and genetic markers are reviewed, and the possibility of tailoring personal treatment is discussed.
克罗恩病（CD）是一种异质性疾病，可累及胃肠道的任何节段。CD的发病机制尚不清楚，但被认为涉及在遗传易感宿主中由环境因素触发的失控免疫反应。疾病发病机制和临床过程的异质性，再加上对治疗的可变反应及其相关副作用，营造了一个复杂治疗决策的环境。尽管存在这种复杂性，但已经取得了重大进展，使医生能够开始并预测疾病行为、自然病程、对治疗的反应以及与严重副作用相关的因素。在本手稿中，回顾了与这些变量相关的数据，包括临床、内镜以及各种生物学和遗传标志物，并讨论了定制个性化治疗的可能性。
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