Somerville R, Lackson A, Zhou S, Fletcher C, Fitzpatrick P
UCD School of Public Health Physiotherapy and Population Science, Belfield, Dublin 4.
Ir Med J. 2013 Jun;106(6):166-8.
The international literature shows that the demography of cystic fibrosis (CF) is changing, with patients increasingly surviving into adulthood. As they age, patients with CF become more susceptible to specific non-pulmonary chronic diseases. In this study, adult data from the CF Registry of Ireland (CFRI) was used to determine the prevalence and associated features of these diseases. 104 (25.7%) adults had diabetes versus 13 (2.9%) children (p < 0.001). Liver disease was present in 47 (11.6%) adults and 26 (5.7%) children (p = 0.002). 173 (42.7%) adults had bone disease versus 25 (5.5%) children (p < 0.001). Adults with one non-pulmonary chronic disease, for example liver disease, were more likely to have another (p = 0.002), those with diabetes and bone disease had a higher number of hospital admissions in the last 12 months (p < 0.001 for both) and higher rates of depression (p = 0.046 and p = 0.049, respectively). These results highlight a number of challenges for the Irish healthcare system.
国际文献表明，囊性纤维化（CF）的人口统计学特征正在发生变化，患者存活至成年的人数越来越多。随着年龄增长，CF患者更容易患上特定的非肺部慢性疾病。在本研究中，爱尔兰囊性纤维化注册处（CFRI）的成人数据被用于确定这些疾病的患病率及相关特征。104名（25.7%）成人患有糖尿病，而儿童中有13名（2.9%）患病（p<0.001）。47名（11.6%）成人和26名（5.7%）儿童患有肝病（p = 0.002）。173名（42.7%）成人患有骨病，而儿童中有25名（5.5%）患病（p<0.001）。患有一种非肺部慢性疾病（如肝病）的成人更有可能患有另一种疾病（p = 0.002），患有糖尿病和骨病的患者在过去12个月的住院次数更多（两者p均<0.001），且抑郁症发病率更高（分别为p = 0.046和p = 0.049）。这些结果凸显了爱尔兰医疗系统面临的一些挑战。
