2 型固有免疫细胞在变应性哮喘中的作用。

Myeloid dendritic cells type 2 in allergic asthma.

机构信息

Firestone Institute of Respiratory Health, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

出版信息

Allergy. 2013 Oct;68(10):1322-6. doi: 10.1111/all.12212. Epub 2013 Aug 3.

DOI:10.1111/all.12212

PMID:23909255

Abstract

BACKGROUND

Myeloid dendritic cells type 2 (mDC2s) are a new subtype of DCs identified in both the circulation and the lung and suggested to have a role in allergic asthma.

METHODS

Circulating mDC2s were enumerated in 19 healthy, 18 atopic nonasthmatic, 18 mild atopic asthmatic, and 16 moderate/severe atopic asthmatic subjects using flow cytometry.

RESULTS

The number of circulating mDC2s was significantly lower in atopic subjects compared with healthy controls and in asthmatic subjects compared with nonasthmatic subjects. There was a trend toward lower levels of circulating mDC2s with increasing allergy and asthma severity. The largest differences were seen in moderate/severe atopic asthmatics being 430.78 ± 48.91/ml compared with healthy controls being 767.05 ± 101.64/ml (P < 0.05).

CONCLUSIONS

Circulating mDC2s are lower in atopic and asthmatic subjects, which suggests that these cells efflux from the blood into the airways in patients with allergic disease.

摘要

背景

髓系树突状细胞 2 型（mDC2）是在循环系统和肺部中发现的一种新的树突状细胞亚型，被认为在过敏性哮喘中起作用。

方法

使用流式细胞术对 19 名健康对照者、18 名特应性非哮喘者、18 名轻度特应性哮喘者和 16 名中重度特应性哮喘者进行循环 mDC2 计数。

结果

与健康对照组相比，特应性受试者的循环 mDC2 数量明显较低，与非哮喘受试者相比，哮喘受试者的循环 mDC2 数量也较低。循环 mDC2 水平随过敏和哮喘严重程度的增加呈下降趋势。中重度特应性哮喘患者的差异最大，为 430.78 ± 48.91/ml，而健康对照组为 767.05 ± 101.64/ml（P < 0.05）。