School of Basic Medical Sciences, Public Center of Experimental Technology, Southwest Medical University, Luzhou, Sichuan, China.
School of Stomatology, Southwest Medical University, Luzhou, Sichuan, China.
Front Immunol. 2024 Oct 28;15:1481989. doi: 10.3389/fimmu.2024.1481989. eCollection 2024.
Dendritic cells (DCs), specialized antigen-presenting cells of the immune system, act as immunomodulators in diseases of the immune system, including asthma. The understanding of DC biology has evolved over the years to include multiple subsets of DCs with distinct functions in the initiation and maintenance of asthma. Moreover, most strategies for treating asthma with relevant therapeutic agents that target DCs have been initiated from the study of DC function. We discussed the pathogenesis of asthma (including T2-high and T2-low), the roles played by different DC subpopulations in the pathogenesis of asthma, and the therapeutic strategies centered around DCs. This study will provide a scientific theoretical basis for current asthma treatment, provide theoretical guidance and research ideas for developing and studying therapeutic drugs targeting DC, and provide more therapeutic options for the patient population with poorly controlled asthma symptoms.
树突状细胞（DCs）是免疫系统中专门的抗原呈递细胞，在包括哮喘在内的免疫系统疾病中发挥免疫调节剂作用。近年来，人们对 DC 生物学的认识不断发展，包括具有不同功能的多个 DC 亚群，这些亚群在哮喘的发生和维持中发挥作用。此外，大多数使用针对 DC 的相关治疗药物治疗哮喘的策略都是从研究 DC 功能开始的。我们讨论了哮喘的发病机制（包括 T2 高和 T2 低）、不同 DC 亚群在哮喘发病机制中的作用以及以 DC 为中心的治疗策略。这项研究将为当前的哮喘治疗提供科学的理论基础，为开发和研究针对 DC 的治疗药物提供理论指导和研究思路，并为哮喘症状控制不佳的患者群体提供更多的治疗选择。
