Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Microbiol Immunol. 2013 Oct;57(10):715-22. doi: 10.1111/1348-0421.12086.
Immunological responses to influenza vaccination administered to liver transplantation recipients are not fully elucidated. To compare inactivated influenza vaccine's immunogenicity between adult and pediatric recipients, 16 adult and 15 pediatric living donor liver transplantation recipients in the 2010-11 influenza season, and 53 adult and 21 pediatric recipients in the 2011-12 season, were investigated. Seroprotection rates (hemagglutinin-inhibition [HI] antibody titer 1:40) were 50-94% to all three antigens among adults and 27-80% among children in both seasons. Seroconversion rates (fourfold or more HI antibody rise) were 32-56% among adults and 13-67% among children in both seasons. No significant differences were observed between the two groups. In addition, 20/53 adult and 13/21 pediatric recipients received a vaccine containing identical antigens in both of these seasons. Geometric mean titer fold increases of all three antigens in adult recipients were significantly lower than those in recipients who had not received a preceding vaccination. In contrast, in pediatric recipients, there were no significant differences between the groups who had and had not received preceding vaccinations. The number of patients with rejection did not differ significantly between the two groups (0/53 vs. 1/21) in the 2011-12 season. The incidence of influenza after vaccination was significantly different between adult and pediatric recipients (0/16 vs. 5/15 in 2010-11 and 0/53 vs. 3/21 in 2011-12, respectively). Overall, there were no significant differences in antibody responses between adult and pediatric groups. Influenza infection was more frequent in pediatric recipients. Long-term response to preceding vaccinations appeared to be insufficient in both groups.
接种于肝移植受者的流感疫苗的免疫反应尚未完全阐明。为了比较成人和儿科受者的灭活流感疫苗的免疫原性，我们调查了 2010-11 流感季节的 16 名成人和 15 名儿科活体供肝移植受者，以及 2011-12 季节的 53 名成人和 21 名儿科受者。在两个季节中，所有三种抗原的成人血清保护率（血凝抑制[HI]抗体滴度 1：40）为 50-94％，儿童为 27-80％。成人的血清转化率（HI 抗体增加四倍或更多）为 32-56％，儿童为 13-67％。两组之间没有观察到显著差异。此外，在这两个季节中，20/53 名成人和 13/21 名儿科受者接受了含有相同抗原的疫苗。成人所有三种抗原的几何平均滴度倍数增加均明显低于未接受先前疫苗接种的受者。相比之下，在儿科受者中，未接受和接受先前疫苗接种的两组之间没有显著差异。在 2011-12 季节中，两组的排斥反应患者数量没有显著差异（0/53 与 1/21）。接种疫苗后流感的发生率在成人和儿科受者之间存在显著差异（0/16 与 0/15 在 2010-11 年，0/53 与 3/21 在 2011-12 年）。总体而言，两组之间的抗体反应没有明显差异。儿科受者中流感感染更为频繁。两组中先前疫苗接种的长期反应似乎均不足。
