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[通过毛发分析检测可待因滥用情况]

[The detection of codeine abuse by hair analysis].

作者信息

Scheller M, Sachs H

机构信息

Abteilung Rechtsmedizin, Klinikum der Universität Ulm.

出版信息

Dtsch Med Wochenschr. 1990 Aug 31;115(35):1313-5. doi: 10.1055/s-2008-1065159.

DOI:10.1055/s-2008-1065159
PMID:2390947
Abstract

For the purpose of assessing possible opiate dependence (question of culpability) toxicological tests (gas chromatography; mass-spectrometry) were performed on cuttings of hair of a 30-year-old man who had within a short period committed several punishable offences 8 months previously. It was thus possible to determine opiate intake over a period of time corresponding to the length of hair. About 20 micrograms/g codeine and up to 4 micrograms/g morphine were demonstrated, in addition also 30 micrograms/g bromazepam. These results proved that amounts exceeding therapeutic levels of bromazepam and codeine-containing drugs had been taken during the period in question.

摘要

为了评估可能的阿片类药物依赖(罪责问题),对一名30岁男子的头发样本进行了毒理学检测(气相色谱法;质谱分析法)。该男子在8个月前的短时间内犯下了多项应受惩罚的罪行。由此得以确定与头发长度相对应时间段内的阿片类药物摄入量。检测显示,每克头发中约含20微克可待因,最高含4微克吗啡,此外还含有30微克溴西泮。这些结果证明,在相关时间段内,所摄入的溴西泮和含可待因药物的量超过了治疗水平。

相似文献

1
[The detection of codeine abuse by hair analysis].[通过毛发分析检测可待因滥用情况]
Dtsch Med Wochenschr. 1990 Aug 31;115(35):1313-5. doi: 10.1055/s-2008-1065159.
2
[Hair analysis of abused drugs with gas-chromatography mass spectrometry].
Acta Pharm Hung. 2009;79(2):47-56.
3
Hair analysis by liquid chromatography-tandem mass spectrometry in toxicological investigation of drug-facilitated crimes: report of 128 cases over the period June 2003-May 2004 in metropolitan Paris.液相色谱-串联质谱法在药物辅助犯罪毒理学调查中的毛发分析:2003年6月至2004年5月期间巴黎市区128例报告
Forensic Sci Int. 2005 Oct 4;153(1):3-10. doi: 10.1016/j.forsciint.2005.04.021.
4
Simultaneous determination of morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in hair by liquid chromatography/electrospray ionization tandem mass spectrometry.采用液相色谱/电喷雾电离串联质谱法同时测定毛发中的吗啡、可待因、6-乙酰吗啡、可卡因和苯甲酰爱康宁。
Rapid Commun Mass Spectrom. 2009 Apr;23(7):957-62. doi: 10.1002/rcm.3955.
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Evidence of addiction by anesthesiologists as documented by hair analysis.通过毛发分析记录的麻醉医生成瘾证据。
Forensic Sci Int. 2005 Oct 4;153(1):81-4. doi: 10.1016/j.forsciint.2005.04.033.
6
Evidence of polydrug use using hair analysis: a fatal case involving heroin, cocaine, cannabis, chloroform, thiopental and ketamine.毛发分析显示多药滥用的证据:一例涉及海洛因、可卡因、大麻、氯仿、硫喷妥钠和氯胺酮的致命案例。
J Forensic Sci. 1998 Mar;43(2):435-8.
7
Results of hair analyses for drugs of abuse and comparison with self-reports and urine tests.滥用药物毛发分析结果以及与自我报告和尿液检测的比较。
Forensic Sci Int. 2006 Jan 27;156(2-3):118-23. doi: 10.1016/j.forsciint.2004.07.024.
8
Legal issues of addiction assessment: the experience with hair testing in Greece.
J Appl Toxicol. 2005 Mar-Apr;25(2):143-52. doi: 10.1002/jat.1047.
9
State of the art in hair analysis for detection of drug and alcohol abuse.用于检测药物和酒精滥用的毛发分析技术现状。
Clin Chim Acta. 2006 Aug;370(1-2):17-49. doi: 10.1016/j.cca.2006.02.019. Epub 2006 Mar 6.
10
[Hair analysis in the evaluation of complex drug-poisonings for medico-legal purposes].[毛发分析在法医学目的复杂药物中毒评估中的应用]
Arch Med Sadowej Kryminol. 2004 Apr-Sep;54(2-3):125-38.

引用本文的文献

1
Determination of dihydrocodeine in hair of opiate addicts by GC/MS.
Int J Legal Med. 1993;105(5):247-50. doi: 10.1007/BF01370380.
2
Detection of drugs in human hair for clinical and forensic applications.用于临床和法医应用的人发中药物检测。
Int J Legal Med. 1992;105(1):1-4. doi: 10.1007/BF01371228.