Dept. of Food Science, School of Food Engineering, Univ. of Campinas, Rua Monteiro Lobato, 80, 13083-862 Campinas, SP, Brazil.
J Food Sci. 2013 Sep;78(9):R1321-33. doi: 10.1111/1750-3841.12222. Epub 2013 Aug 1.
Aquaculture has become an important source of fish available for human consumption. In order to achieve greater productivity, intensive fish cultivation systems are employed, which can cause greater susceptibility to diseases caused by viruses, bacteria, fungi, and parasites. Antimicrobial substances are compounds used in livestock production with the objectives of inhibiting the growth of microorganisms and treatment or prevention of diseases. It is well recognized that the issues of antimicrobial use in food animals are of global concern about its impact on food safety. This paper present an overview of the aquaculture production in the whole world, raising the particularities in Brazil, highlighting the importance of the use of veterinary drugs in this system of animal food production, and address the potential risks arising from their indiscriminate use and their impacts on aquaculture production as they affect human health and the environment. The manuscript also discusses the analytical methods commonly used in the determination of veterinary drug residues in fish, with special issue for fluroquinolones residues and with emphasis on employment of LC-MS/MS analytical technique.
水产养殖已成为人类可食用鱼类的重要来源。为了实现更高的生产力，密集型鱼类养殖系统被采用，这可能导致鱼类更容易受到病毒、细菌、真菌和寄生虫引起的疾病的影响。抗菌物质是用于畜牧业生产的化合物，其目的是抑制微生物的生长以及治疗或预防疾病。人们普遍认识到，在食用动物中使用抗菌药物的问题是全球关注的焦点，因为它会对食品安全产生影响。本文概述了全球水产养殖生产情况，提出了巴西的特殊性，强调了在这种动物食品生产系统中使用兽药的重要性，并讨论了其滥用以产生的潜在风险及其对水产养殖生产的影响，因为这会影响人类健康和环境。本文还讨论了常用于鱼类中兽药残留检测的分析方法，特别提到了氟喹诺酮类药物残留问题，并重点介绍了 LC-MS/MS 分析技术的应用。
