• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Genetic variability of inflammatory genes in the Brazilian population.巴西人群中炎症基因的遗传变异性。
Genet Test Mol Biomarkers. 2013 Nov;17(11):844-8. doi: 10.1089/gtmb.2013.0264. Epub 2013 Aug 3.
2
Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.长寿命 T 细胞、肿瘤坏死因子、LST1 和 HLA 基因单倍型及其与风疹疫苗诱导免疫的关系。
PLoS One. 2010 Jul 27;5(7):e11806. doi: 10.1371/journal.pone.0011806.
3
[Relationship between FAS/FASL gene polymorphisms and susceptibility of coal worker's pneumoconiosis].[FAS/FASL基因多态性与煤工尘肺易感性的关系]
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Sep;25(9):532-6.
4
TNF alpha and LT alpha gene polymorphisms as additional markers of celiac disease susceptibility in a DQ2-positive population.肿瘤坏死因子α和淋巴毒素α基因多态性作为DQ2阳性人群中乳糜泻易感性的附加标志物。
Immunogenetics. 2002 Nov;54(8):551-5. doi: 10.1007/s00251-002-0498-9. Epub 2002 Oct 3.
5
Functional genetic variants in apoptosis-associated FAS and FASL genes and risk of bladder cancer in a Turkish population.土耳其人群中凋亡相关FAS和FASL基因的功能遗传变异与膀胱癌风险
In Vivo. 2014 May-Jun;28(3):397-402.
6
Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis.特发性肺纤维化患者肿瘤坏死因子-α、淋巴毒素-α、肿瘤坏死因子受体II及白细胞介素-6基因多态性分析
Am J Respir Crit Care Med. 2001 May;163(6):1432-6. doi: 10.1164/ajrccm.163.6.2006064.
7
Genetic Distribution of the +252 A>G and -308 G > A Polymorphisms in the Moroccan Population.摩洛哥人群中 +252 A>G和 -308 G>A多态性的基因分布
Genet Test Mol Biomarkers. 2019 Dec;23(12):871-876. doi: 10.1089/gtmb.2019.0116. Epub 2019 Nov 18.
8
TNFA-TNFB haplotypes modify susceptibility to type I diabetes mellitus independently of HLA class II in a Moroccan population.在摩洛哥人群中，TNFA - TNFB单倍型独立于HLA - II类基因，改变对I型糖尿病的易感性。
Tissue Antigens. 2003 Jan;61(1):72-9. doi: 10.1034/j.1399-0039.2003.610106.x.
9
Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism.严重全身炎症反应综合征的成年重症监护患者死亡率与低免疫 TNF -238A 多态性密切相关。
Immunogenetics. 2009 Oct;61(10):657-62. doi: 10.1007/s00251-009-0395-6. Epub 2009 Aug 28.
10
Recurrent miscarriage and variant alleles of mannose binding lectin, tumour necrosis factor and lymphotoxin alpha genes.复发性流产与甘露糖结合凝集素、肿瘤坏死因子及淋巴毒素α基因的变异等位基因
Clin Exp Immunol. 2001 Dec;126(3):529-34. doi: 10.1046/j.1365-2249.2001.01663.x.

引用本文的文献

1
Single-Base Gene Variants in and Genes Related to the Epileptogenic Process in Drug-Responsive and Drug-Resistant Temporal Lobe Epilepsy-A Preliminary Study in a Brazilian Cohort Sample.基因和 基因中的单碱基基因变异与药物反应性和耐药性颞叶癫痫的致痫过程相关-巴西队列样本的初步研究。
Int J Mol Sci. 2024 May 30;25(11):6005. doi: 10.3390/ijms25116005.
2
APOBEC3A/B Polymorphism Is Not Associated with Human Papillomavirus Infection and Cervical Carcinogenesis.载脂蛋白B编辑酶催化多肽样3A/B多态性与人类乳头瘤病毒感染及宫颈癌发生无关。
Pathogens. 2023 Apr 23;12(5):636. doi: 10.3390/pathogens12050636.
3
Characterization of demographic data, clinical signs, comorbidities, and outcomes according to the race in hospitalized individuals with COVID-19 in Brazil: An observational study.根据巴西住院 COVID-19 患者的种族对人口统计学数据、临床症状、合并症和结局进行特征描述：一项观察性研究。
J Glob Health. 2022 Jul 25;12:05027. doi: 10.7189/jogh.12.05027.
4
The hindrances to perform the COVID-19 vaccination in Brazil.巴西实施 COVID-19 疫苗接种的障碍。
Hum Vaccin Immunother. 2021 Nov 2;17(11):3989-4004. doi: 10.1080/21645515.2021.1955607. Epub 2021 Aug 5.
5
Single-Nucleotide Variants in microRNAs Sequences or in their Target Genes Might Influence the Risk of Epilepsy: A Review.单核苷酸变异在 microRNAs 序列或其靶基因中可能影响癫痫的风险：综述。
Cell Mol Neurobiol. 2022 Aug;42(6):1645-1658. doi: 10.1007/s10571-021-01058-7. Epub 2021 Mar 5.
6
Childhood overweight and obesity in a region of Italian immigration in Southern Brazil: a cross-sectional study.巴西南部意大利移民聚居地区儿童超重与肥胖情况：一项横断面研究
Ital J Pediatr. 2015 Apr 2;41:28. doi: 10.1186/s13052-015-0126-6.

本文引用的文献

1
The IkappaBL gene polymorphism influences risk of acquiring systemic lupus erythematosus and Sjögren's syndrome.IkappaBL基因多态性影响患系统性红斑狼疮和干燥综合征的风险。
Hum Immunol. 2008 Jan;69(1):45-51. doi: 10.1016/j.humimm.2007.11.008. Epub 2007 Dec 26.
2
Inflammation, atherosclerosis, and coronary artery disease.炎症、动脉粥样硬化与冠状动脉疾病。
N Engl J Med. 2005 Apr 21;352(16):1685-95. doi: 10.1056/NEJMra043430.
3
Inflammatory process in Parkinson's disease: role for cytokines.帕金森病中的炎症过程：细胞因子的作用
Curr Pharm Des. 2005;11(8):999-1016. doi: 10.2174/1381612053381620.
4
Inflammation as a tumor promoter in cancer induction.炎症作为癌症诱导中的肿瘤促进因子。
Semin Cancer Biol. 2004 Dec;14(6):433-9. doi: 10.1016/j.semcancer.2004.06.006.
5
The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease.全身炎症对脑部炎症的影响：对慢性神经退行性疾病的启示
Brain Behav Immun. 2004 Sep;18(5):407-13. doi: 10.1016/j.bbi.2004.01.004.
6
Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis.慢性阻塞性肺疾病与全身炎症之间的关联：一项系统评价与荟萃分析。
Thorax. 2004 Jul;59(7):574-80. doi: 10.1136/thx.2003.019588.
7
Inflammation as a cardiovascular risk factor.炎症作为一种心血管危险因素。
Circulation. 2004 Jun 1;109(21 Suppl 1):II2-10. doi: 10.1161/01.CIR.0000129535.04194.38.
8
Cytokines in the rheumatic diseases.风湿性疾病中的细胞因子。
Rheum Dis Clin North Am. 2004 Feb;30(1):41-67, v-vi. doi: 10.1016/S0889-857X(03)00115-7.
9
Historical genetics: spatiotemporal analysis of the formation of the Brazilian population.历史遗传学：巴西人口形成的时空分析
Am J Hum Biol. 2003 Nov-Dec;15(6):824-34. doi: 10.1002/ajhb.10217.
10
Chronic inflammation as inductor of pro-cancer microenvironment: pathogenesis of dysregulated feedback control.慢性炎症作为促癌微环境的诱导因素：失调的反馈控制机制
Cancer Metastasis Rev. 2003 Mar;22(1):95-102. doi: 10.1023/a:1022220219975.

巴西人群中炎症基因的遗传变异性。

Genetic variability of inflammatory genes in the Brazilian population.

作者信息

dos Santos Marcelo, Stur Elaine, Maia Lucas Lima, Agostini Lidiane Pignaton, Peterle Gabriela Tonini, Mendes Suzanny Oliveira, Tajara Eloiza Helena, de Carvalho Marcos Brasilino, Louro Iúri Drumond, Silva-Conforti Adriana Madeira Álvares

机构信息

1 Programa de Pós Graduação em Biotecnologia, Universidade Federal do Espírito Santo , Vitória, Espírito Santo, Brazil .

出版信息

Genet Test Mol Biomarkers. 2013 Nov;17(11):844-8. doi: 10.1089/gtmb.2013.0264. Epub 2013 Aug 3.

DOI:10.1089/gtmb.2013.0264
PMID:23909556
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3816776/
Abstract

Inflammatory gene variants have been associated with several diseases, including cancer, diabetes, vascular diseases, neurodegenerative diseases, arthritis, and others. Therefore, determining the population genetic composition of inflammation-related genes can be useful for the determination of general risk, prognostic and therapeutic strategies to prevent or cure specific diseases. We have aimed to identify polymorphism genotype frequencies in genes related to the inflammatory response in the Brazilian population, namely, IκBL -62AT, IκBL -262CT, tumor necrosis factors alpha (TNFa) -238GA, TNFa -308GA, lymphotoxin-alpha (LTa) +80AC, LTa +252AG, FAS -670AG, and FASL -844TC, considering the white, black, and Pardo ethnicities of the São Paulo State. Our results suggest that the Brazilian population is under a miscegenation process at the current time, since some genotypes are not in the Hardy-Weinberg equilibrium. In addition, we conclude that the Pardo ethnicity is derived from a complex mixture of ethnicities, including the native Indian population.

摘要

炎症基因变异与多种疾病相关，包括癌症、糖尿病、血管疾病、神经退行性疾病、关节炎等。因此，确定炎症相关基因的群体遗传组成对于确定预防或治疗特定疾病的总体风险、预后和治疗策略可能是有用的。我们旨在确定巴西人群中与炎症反应相关基因的多态性基因型频率，即IκBL -62AT、IκBL -262CT、肿瘤坏死因子α（TNFa）-238GA、TNFa -308GA、淋巴毒素-α（LTa）+80AC、LTa +252AG、FAS -670AG和FASL -844TC，研究对象为圣保罗州的白人、黑人和帕尔多人种。我们的结果表明，巴西人群目前正处于混血过程中，因为一些基因型不符合哈迪-温伯格平衡。此外，我们得出结论，帕尔多人种源自包括本土印第安人群体在内的多种族复杂混合。