Arend William P, Gabay Cem
Division of Rheumatology, University of Colorado Health Sciences Center B1115, 4200 East Ninth Avenue, Denver, CO 80262, USA.
Rheum Dis Clin North Am. 2004 Feb;30(1):41-67, v-vi. doi: 10.1016/S0889-857X(03)00115-7.
Extensive data has accumulated over the last 10 to 15 years to implicate various cytokines in pathways of pathophysiology in rheumatic diseases. Abnormalities in cytokine production are not the cause of these diseases, but reflect continual production by immune and inflammatory cells. Cytokines are heterogeneous and function in an overlapping and redundant network. An important principle to emerge is that the net biologic response in a diseased organ or tissue reflects a balance between the local levels of proinflammatory and anti-inflammatory cytokines and factors. Thus, a chronic disease may result from the excess production of proinflammatory cytokines or the inadequate production of anti-inflammatory cytokines. This article summarizes the role of cytokines in rheumatic diseases by focusing on each disease and the involved pathways of pathophysiology.
在过去10到15年里积累了大量数据，表明各种细胞因子参与了风湿性疾病的病理生理途径。细胞因子产生异常并非这些疾病的病因，而是反映了免疫细胞和炎症细胞的持续产生。细胞因子具有异质性，在一个重叠且冗余的网络中发挥作用。一个重要的原则是，患病器官或组织中的净生物学反应反映了促炎细胞因子和抗炎细胞因子及因子的局部水平之间的平衡。因此，慢性疾病可能是由于促炎细胞因子产生过多或抗炎细胞因子产生不足所致。本文通过关注每种疾病及其涉及的病理生理途径，总结了细胞因子在风湿性疾病中的作用。
