3rd Institute of Physics and Research Center SCOPE, University Stuttgart , Stuttgart 70569, Germany.
Nano Lett. 2013 Sep 11;13(9):4093-8. doi: 10.1021/nl401522a. Epub 2013 Aug 6.
Sensing and imaging paramagnetic species under physiological conditions is a key technology in chemical and biochemical analytics, cell biology, and medical sciences. At submicrometer length scales, nitrogen-vacancy (NV) centers in diamond offer atom-sized probes for magnetic fields. We show that spin relaxation of an ensemble NV sensor allows sensing of adsorbed and freely diffusing manganese(II) ions and adsorbed ferritin. Sensitivities approach 175 Mn ions and 10 ferritin proteins per diffraction limited spot under ambient conditions.
在生理条件下感应和成像顺磁物种是化学和生物化学分析、细胞生物学和医学科学的关键技术。在亚微米长度尺度下，钻石中的氮空位 (NV) 中心为磁场提供了原子大小的探针。我们表明，集合 NV 传感器的自旋弛豫允许感应吸附和自由扩散的锰 (II) 离子和吸附的铁蛋白。在环境条件下，灵敏度接近每个衍射限制点 175 个 Mn 离子和 10 个铁蛋白。
