金催化 2-炔基芳基叠氮化物衍生物合成功能化喹啉。
Au-catalyzed formation of functionalized quinolines from 2-alkynyl arylazide derivatives.
机构信息
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique, Ecole Polytechnique, 91128 Palaiseau, France.
出版信息
Org Lett. 2013 Aug 16;15(16):4234-7. doi: 10.1021/ol4019634. Epub 2013 Aug 2.
PMID:23909764
Abstract
A new method for converting 2-alkynyl arylazide derivatives into functionalized polysubstituted quinolines following a gold-catalyzed 1,3-acetoxy shift/cyclization/1,2-group shift sequence has been developed. This transformation proceeds under mild reaction conditions, is efficient, and tolerates a large variety of functional groups.
摘要
一种新的方法，用于在金催化的 1,3-乙酰氧基转移/环化/1,2-基团转移序列后，将 2-炔基芳基叠氮衍生物转化为功能化的多取代喹啉衍生物。该转化在温和的反应条件下进行，效率高，并且可以容忍多种官能团。
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