氮芥、长春新碱、美法仑和泼尼松（MOMP）用于治疗犬复发性淋巴瘤。
Mechlorethamine, vincristine, melphalan and prednisone (MOMP) for the treatment of relapsed lymphoma in dogs.
作者信息
Back A R, Schleis S E, Smrkovski O A, Lee J, Smith A N, Phillips J C
机构信息
Comparative Oncology Program, Department of Clinical Sciences, Auburn University, College of Veterinary Medicine, Auburn, AL, USA.
Comparative Oncology Program, Department of Small Animal Medicine, University of Tennessee, College of Veterinary Medicine, Knoxville, TN, USA.
出版信息
Vet Comp Oncol. 2015 Dec;13(4):398-408. doi: 10.1111/vco.12055. Epub 2013 Aug 5.
Eighty-eight dogs with relapsed lymphoma were treated with the MOMP (mechlorethamine, vincristine, melphalan and prednisone) protocol on a 28-day treatment cycle. The overall response rate (ORR) to the MOMP protocol was 51.1% for a median of 56 days (range 7-858 days). Twelve percent of dogs experienced a complete response for a median of 81 days (range 42-274 days) and 38.6% experienced a partial response for a median of 49 days (range 7-858 days). Dogs with T-cell lymphoma had an ORR of 55% for a median of 60 days (range 49-858 days) while those with B-cell lymphoma had an ORR of 57% for a median of 81 days (range 7-274 days) (P = 0.783). The overall survival time for all dogs was 183 days (range 17-974 days). Fifty-four percent of dogs experienced toxicity with the majority classified as grade I. The MOMP protocol seems well-tolerated and is an option for dogs with relapsed lymphoma.
88只复发淋巴瘤犬接受了MOMP（氮芥、长春新碱、美法仑和泼尼松）方案治疗，治疗周期为28天。MOMP方案的总缓解率（ORR）为51.1%，中位缓解时间为56天（范围7 - 858天）。12%的犬达到完全缓解，中位缓解时间为81天（范围42 - 274天），38.6%的犬达到部分缓解，中位缓解时间为49天（范围7 - 858天）。T细胞淋巴瘤犬的ORR为55%，中位缓解时间为60天（范围49 - 858天），而B细胞淋巴瘤犬的ORR为57%，中位缓解时间为81天（范围7 - 274天）（P = 0.783）。所有犬的总生存时间为183天（范围17 - 974天）。54%的犬出现毒性反应，大多数为I级。MOMP方案似乎耐受性良好，是复发淋巴瘤犬的一种治疗选择。
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