重编免疫：从 hESC 产生功能性胸腺……我们做到了吗？

Rewiring immunity: generating a functional thymus from hESCs… are we there yet?

机构信息

Department of Anatomy and Developmental Biology, Monash University, Clayton, 3800, Victoria, Australia.

出版信息

Cell Stem Cell. 2013 Aug 1;13(2):135-6. doi: 10.1016/j.stem.2013.07.015.

DOI:10.1016/j.stem.2013.07.015

Abstract

Two papers in this issue of Cell Stem Cell have made a significant advance in solving one of the great challenges of modern immunology-resurrecting thymus function through the induction of thymus epithelial cells (TECs) by directed differentiation of human embryonic stem cells (hESCs).

摘要

本期《细胞-干细胞》中的两篇论文在解决现代免疫学的一个重大挑战方面取得了重大进展，即通过定向分化人类胚胎干细胞（hESC）来诱导胸腺上皮细胞（TEC），从而恢复胸腺功能。