Hamano S, Goto N, Nara T, Yamaguchi K, Maekawa K
Division of Neurology, Saitama Children's Medical Centre, Japan.
Dev Med Child Neurol. 1990 Jul;32(7):621-8. doi: 10.1111/j.1469-8749.1990.tb08546.x.
Anatomical development of the human mesencephalic trigeminal nucleus was assessed quantitatively and qualitatively, using serial sections of brains, with the help of a computer-assisted image-analyser. Five fetuses at 16, 18, 21, 23 and 27 weeks of gestation; five neonates at 30, 32, 33, 35 and 40 weeks of gestation; a two-month-old infant and a 63-year-old adult were studied. Morphometric analyses of the mesencephalic trigeminal nucleus revealed that orocaudal columnar length and neuronal areas gradually increased with gestational age. Diversity of neuronal areas appeared after 32 weeks of gestation, but neuronal numbers and shapes showed little change throughout prenatal and postnatal life.
借助计算机辅助图像分析仪，利用脑连续切片对人类中脑三叉神经核的解剖发育进行了定量和定性评估。研究了5例妊娠16、18、21、23和27周的胎儿；5例妊娠30、32、33、35和40周的新生儿；1例2个月大的婴儿和1例63岁的成年人。中脑三叉神经核的形态计量学分析显示，口尾柱状长度和神经元面积随胎龄逐渐增加。神经元面积的多样性在妊娠32周后出现，但神经元数量和形状在产前和产后整个生命过程中变化不大。
