School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, China.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):3745-52. doi: 10.1016/j.msec.2013.05.004. Epub 2013 May 9.
Hybrid CaCO3 microparticles coated by sodium poly(styrene sulfonate) (PSS) and aliphatic poly(urethane-amine) (PUA) were developed as thermal-/pH-responsive drug delivery vehicles via LbL self-assembly technique. The DOX release from the CaCO3 microparticles was higher than 60% within 36 h, whereas the value of PUA/PSS-coated microparticles was only 20%. The results demonstrated that the PUA/PSS multilayer coating could reduce the drug release rate and significantly assuage the initial burst release of DOX. In addition, the drug release of the hybrid microparticles was found to be thermal-/pH-dual responsive. More interestingly, more than 90% of DOX was released in 36 h at pH2.1 and 55 °C owing to the combined action of the dissolution of the CaCO3 core and the shrinkage of aliphatic PUA.
通过 LbL 自组装技术，制备了同时具有温敏性和 pH 响应性的双亲性碳酸钙（CaCO3）复合纳米微球作为药物载体。与 PUA/PSS 涂层的 CaCO3 微球相比，DOX 从 PUA/PSS 涂层的 CaCO3 微球中的释放率超过 60%，而 PUA/PSS 涂层的 CaCO3 微球中的释放率仅为 20%。结果表明，PUA/PSS 多层涂层可以降低药物的释放速率，并显著减轻 DOX 的初始突释。此外，还发现复合微球的药物释放具有温敏性和 pH 响应性。更有趣的是，在 pH2.1 和 55°C 的条件下，由于 CaCO3 内核的溶解和脂肪族 PUA 的收缩的协同作用，超过 90%的 DOX 在 36 h 内被释放。
