National Engineering Research Center for Magnesium Alloys, College of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):3832-8. doi: 10.1016/j.msec.2013.05.020. Epub 2013 May 16.
The effects of Mn substitution for Mg on the microstructure, mechanical properties, and corrosion behavior of Mg69-xZn27Ca4Mnx (x=0, 0.5 and 1at.%) alloys were investigated using X-ray diffraction, compressive tests, electrochemical treatments, and immersion tests, respectively. Microstructural observations showed that the Mg69Zn27Ca4 alloy was mainly amorphous. The addition of Mn decreases the glass-forming ability, which results in a decreased strength from 545 MPa to 364 MPa. However, this strength is still suitable for implant application. Polarization and immersion tests in the simulated body fluid at 37 °C revealed that the Mn-doped Mg-Zn-Ca alloys have significantly higher corrosion resistance than traditional ZK60 and pure Mg alloys. Cytotoxicity test showed that cell viabilities of osteoblasts cultured with Mn-doped Mg-Zn-Ca alloys extracts were higher than that of pure Mg. Mg68.5Zn27Ca4Mn0.5 exhibits the highest bio-corrosion resistance, biocompatibility and has desirable mechanical properties, which could suggest to be used as biomedical materials in the future.
采用 X 射线衍射、压缩试验、电化学处理和浸泡试验分别研究了 Mn 取代 Mg 对 Mg69-xZn27Ca4Mnx（x=0、0.5 和 1at.%）合金微观结构、力学性能和腐蚀行为的影响。微观结构观察表明，Mg69Zn27Ca4 合金主要为非晶态。Mn 的添加降低了玻璃形成能力，导致强度从 545MPa 降低至 364MPa。然而，这种强度仍适用于植入物应用。在 37°C 的模拟体液中的极化和浸泡试验表明，掺杂 Mn 的 Mg-Zn-Ca 合金的耐腐蚀性明显高于传统的 ZK60 和纯 Mg 合金。细胞毒性试验表明，与纯 Mg 相比，用掺杂 Mn 的 Mg-Zn-Ca 合金浸提液培养的成骨细胞的细胞活力更高。Mg68.5Zn27Ca4Mn0.5 表现出最高的耐生物腐蚀性、生物相容性和理想的力学性能，有望在未来用作生物医学材料。
