Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, CEP 13566-590, Brazil.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4081-5. doi: 10.1016/j.msec.2013.05.051. Epub 2013 Jun 4.
The preparation and electrochemical characterization of a carbon paste electrode modified with the N,N-ethylene-bis(salicyllideneiminato)oxovanadium (IV) complex ([VO(salen)]) as well as its application for ranitidine determination are described. The electrochemical behavior of the modified electrode for the electroreduction of ranitidine was investigated using cyclic voltammetry, and analytical curves were obtained for ranitidine using linear sweep voltammetry (LSV) under optimized conditions. The best voltammetric response was obtained for an electrode composition of 20% (m/m) [VO(salen)] in the paste, 0.10 mol L(-1) of KCl solution (pH 5.5 adjusted with HCl) as supporting electrolyte and scan rate of 25 mV s(-1). A sensitive linear voltammetric response for ranitidine was obtained in the concentration range from 9.9×10(-5) to 1.0×10(-3) mol L(-1), with a detection limit of 6.6×10(-5) mol L(-1) using linear sweep voltammetry. These results demonstrated the viability of this modified electrode as a sensor for determination, quality control and routine analysis of ranitidine in pharmaceutical formulations.
描述了一种用 N,N-亚乙基双（水杨醛亚氨基）氧钒（IV）配合物([VO(salen)])修饰的碳糊电极的制备及其电化学特性，以及其在雷尼替丁测定中的应用。采用循环伏安法研究了修饰电极对雷尼替丁电化学还原的行为，在优化条件下，采用线性扫描伏安法（LSV）得到了雷尼替丁的分析曲线。在糊剂中含有 20%（m/m）[VO(salen)]、0.10 mol L(-1) KCl 溶液（用 HCl 调节 pH 至 5.5）作为支持电解质和 25 mV s(-1)的扫描速率时，电极得到最佳的伏安响应。在 9.9×10(-5)至 1.0×10(-3) mol L(-1)的浓度范围内，雷尼替丁得到灵敏的线性伏安响应，线性扫描伏安法的检测限为 6.6×10(-5) mol L(-1)。这些结果表明，这种修饰电极作为传感器，可用于药物制剂中雷尼替丁的测定、质量控制和常规分析。
