Department of Chemistry, Faculty of Science, Yazd University, Safa-ieh, Yazd, Islamic Republic of Iran.
Colloids Surf B Biointerfaces. 2010 Mar 1;76(1):82-7. doi: 10.1016/j.colsurfb.2009.10.019. Epub 2009 Oct 20.
A carbon paste electrode (CPE) modified with 2,2'-[1,2 butanediylbis(nitriloethylidyne)]-bis-hydroquinone (BBNBH) and TiO(2) nanoparticles was used for the sensitive voltammetric determination of epinephrine (EP). The electrochemical response characteristics of the modified electrode toward EP and acetaminophen (AC) were investigated by cyclic and differential pulse voltammetry (CV and DPV). The results showed an efficient catalytic activity of the electrode for the electrooxidation of EP, which leads to a reduction in its overpotential by more than 270mV. The effects of pH and potential sweep rate on the mechanism of the electrode process were investigated. The modified electrode exhibits an efficient electron-mediating behavior together with well-separated oxidation peaks for EP and AC. At the optimum pH of 8.0 in a 0.1M phosphate buffer solution, the DPV anodic peak currents showed a linear relationship versus EP concentrations in the range of 1.0-600.0microM and a detection limit of 0.2microM.
一种用 2,2'-[1,2-丁烷二基双（亚硝基亚乙基）]双-对苯二酚（BBNBH）和 TiO2 纳米粒子修饰的碳糊电极（CPE），用于灵敏伏安法测定肾上腺素（EP）。通过循环伏安法和差分脉冲伏安法（CV 和 DPV）研究了修饰电极对 EP 和对乙酰氨基酚（AC）的电化学响应特性。结果表明，电极对 EP 的电氧化具有高效的催化活性，使其过电位降低了 270mV 以上。研究了 pH 值和电位扫描速率对电极过程机制的影响。修饰电极表现出有效的电子中介行为，同时 EP 和 AC 的氧化峰得到很好的分离。在 0.1M 磷酸盐缓冲溶液中最佳 pH 值为 8.0 时，DPV 阳极峰电流与 EP 浓度在 1.0-600.0μM 范围内呈线性关系，检测限为 0.2μM。
