Department of Mechanical, Industrial and Manufacturing Engineering, The University of Toledo, Toledo, OH, USA.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4323-30. doi: 10.1016/j.msec.2013.06.029. Epub 2013 Jun 28.
In this study, we present results of our research on biodegradable monetite (DCPA, CaHPO4) cement with surface-modified multi-walled carbon nanotubes (mMWCNTs) as potential bone defect repair material. The cement pastes showed desirable handling properties and possessed a suitable setting time for use in surgical setting. The incorporation of mMWCNTs shortened the setting time of DCPA and increased the compressive strength of DCPA cement from 11.09±1.85 MPa to 21.56±2.47 MPa. The cytocompatibility of the materials was investigated in vitro using the preosteoblast cell line MC3T3-E1. An increase of cell numbers was observed on both DCPA and DCPA-mMWCNTs. Scanning electron microscopy (SEM) results also revealed an obvious cell growth on the surface of the cements. Based on these results, DCPA-mMWCNTs composite cements can be considered as potential bone defect repair materials.
在这项研究中，我们展示了我们对具有表面改性多壁碳纳米管（mMWCNTs）的可生物降解的单水磷酸氢钙（DCPA，CaHPO4）水泥作为潜在的骨缺损修复材料的研究结果。水泥浆表现出良好的操作性能，并具有适合手术应用的合适凝固时间。mMWCNTs 的掺入缩短了 DCPA 的凝固时间，并将 DCPA 水泥的抗压强度从 11.09±1.85 MPa 提高到 21.56±2.47 MPa。使用前成骨细胞系 MC3T3-E1 体外研究了材料的细胞相容性。在 DCPA 和 DCPA-mMWCNTs 上均观察到细胞数量增加。扫描电子显微镜（SEM）结果还显示出水泥表面上明显的细胞生长。基于这些结果，DCPA-mMWCNTs 复合水泥可被视为潜在的骨缺损修复材料。
