Koju Naresh, Sikder Prabaha, Gaihre Bipin, B Bhaduri Sarit
Department of Mechanical Industrial and Manufacturing Engineering, The University of Toledo, Toledo, OH 43606, USA.
Department of Bioengineering, the University of Toledo, Toledo, OH 43606, USA.
Materials (Basel). 2018 Jul 22;11(7):1258. doi: 10.3390/ma11071258.
The present study is the first of its kind dealing with the development of a specific bioceramic which qualifies as a potential material in hard-tissue replacements. Specifically, we report the synthesis and evaluation of smart injectable calcium phosphate bone cement (CPC) which we believe will be suitable for various kinds of orthopedic and spinal-fusion applications. The smart nature of this next generation orthopedic implant is attained by incorporating piezoelectric barium titanate (BT) particles into monetite-based (dicalcium phosphate anhydrous, DCPA) CPC composition. The main goal is to take advantage of the piezoelectric properties of BT, as electromechanical effect plays a vital role in fracture healing at the defect site and bone integration with the implant. Furthermore, radiopacity of BT would help in easy detection of the CPC presence at the fracture site during surgery. Results reveal that BT addition favors important properties of bone cement such as good compressive strength, injectability, bioactivity, biocompatibility, and even washout resistance. Most importantly, the self-setting nature of the bone cements are not compromised with BT incorporation. The in vitro results confirm that the developed bone-cement abides by the standard orthopedic requirements making it apt for real-time prosthetic materials.
本研究首次涉及一种特定生物陶瓷的研发，这种生物陶瓷有望成为硬组织替代的潜在材料。具体而言，我们报告了智能可注射磷酸钙骨水泥（CPC）的合成与评估，我们认为它适用于各种骨科和脊柱融合应用。这种下一代骨科植入物的智能特性是通过将压电钛酸钡（BT）颗粒掺入基于透钙磷石（无水磷酸二钙，DCPA）的CPC成分中实现的。主要目标是利用BT的压电特性，因为机电效应在缺损部位的骨折愈合以及骨与植入物的整合中起着至关重要的作用。此外，BT的射线不透性有助于在手术过程中轻松检测骨折部位的CPC存在情况。结果表明，添加BT有利于骨水泥的重要性能，如良好的抗压强度、可注射性、生物活性、生物相容性，甚至抗冲洗性。最重要的是，骨水泥的自固化特性不会因掺入BT而受到影响。体外结果证实，所研发的骨水泥符合标准的骨科要求，使其适用于实时假体材料。
