AGES, Institute for Medical Microbiology and Hygiene, Vienna, Austria.
Clin Microbiol Infect. 2014 Jan;20(1):O13-9. doi: 10.1111/1469-0691.12311. Epub 2013 Jul 30.
In 2010 a case of a dual infection with Legionella pneumophila serogroup (sg) 1 and sg 3 was identified by culture of a blood sample collected from a female Austrian patient with septic pneumonia. Subsequently all 35 European National Legionella Reference Laboratories were interviewed regarding the frequency of dual infections in legionellosis. The Reference Laboratories in Denmark, the UK and Germany reported the detection of another 14 cases of dual infections with different Legionella strains between 2002 and 2012. Among the 15 cases, there were four cases with different Legionella species, six cases with different L. pneumophila serogroups, and five cases of dual infections with L. pneumophila sg 1 with different MAb-types. The median age of the 15 cases was 56 years and the male to female ratio 1:1.14. Six of the 15 patients were receiving immunosuppressive treatment following organ transplantation (n = 3) or for underlying haematological and solid malignancies (n = 3). Five of the 15 cases died within 30 days following diagnosis. Efforts to detect dual infections with different Legionella strains will improve our ability to correctly elucidate the causative sources of infection and enhance our understanding of the epidemiology of Legionella infections.
2010 年，从一名患有败血症性肺炎的奥地利女性患者的血样中培养出嗜肺军团菌血清群（sg）1 和 sg3 的双重感染，随后对所有 35 个欧洲国家军团菌参考实验室进行了采访，以了解军团菌病中双重感染的频率。丹麦、英国和德国的参考实验室报告称，在 2002 年至 2012 年间，又检测到了另外 14 例不同军团菌株的双重感染。在这 15 例中，有 4 例为不同的军团菌种，6 例为不同的嗜肺军团菌血清群，5 例为嗜肺军团菌 sg1 与不同单克隆抗体型的双重感染。15 例患者的中位年龄为 56 岁，男女比例为 1:1.14。15 例患者中有 6 例在器官移植后（n=3）或患有潜在的血液系统和实体恶性肿瘤（n=3）接受免疫抑制治疗。15 例中有 5 例在诊断后 30 天内死亡。努力检测不同军团菌株的双重感染将提高我们正确阐明感染源的能力，并增强我们对军团菌感染流行病学的理解。
