Nishizuka Midori, Suzuki Hiroki, Ara Tomoka, Watanabe Mari, Morita Mami, Sato Chisa, Tsuchida Fumihiro, Seto Junji, Amemura-Maekawa Junko, Kura Fumiaki, Takeda Hiroaki
Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
J Infect Chemother. 2014 Jun;20(6):390-3. doi: 10.1016/j.jiac.2014.01.010. Epub 2014 Mar 12.
The patient was an 83-year-old man hospitalized for Haemophilus influenzae pneumonia, who developed recurrent pneumonia after improvement of the initial episode. Legionella pneumophila serogroup 12 was isolated from the sputum, accompanied by increased serum antibody titers to L. pneumophila serogroup 12. Therefore, the patient was diagnosed as having Legionella pneumonia caused by L. pneumophila serogroup 12. Case reports of pneumonia caused by L. pneumophila serogroup 12 are rare, and the case described herein is the first report of clinical isolation of this organism in Japan. When the genotype was determined by the protocol of The European Working Group for Legionella Infections (Sequence-Based Typing [SBT] for epidemiological typing of L. pneumophila, Version 3.1), the sequence type was ST68. Imipenem/cilastatin therapy was found to be effective for the treatment of Legionella pneumonia in this patient.
该患者为一名83岁男性，因流感嗜血杆菌肺炎住院，在初始病情好转后又出现了复发性肺炎。从痰液中分离出嗜肺军团菌血清型12，同时血清中针对嗜肺军团菌血清型12的抗体滴度升高。因此，该患者被诊断为嗜肺军团菌血清型12引起的军团菌肺炎。由嗜肺军团菌血清型12引起的肺炎病例报告很少，本文所述病例是日本首次临床分离出该病原体的报告。按照欧洲军团菌感染工作组的方案（基于序列的分型[SBT]用于嗜肺军团菌的流行病学分型，第3.1版）确定基因型时，序列型为ST68。发现亚胺培南/西司他丁疗法对该患者的军团菌肺炎治疗有效。
