DiNicolantonio James J, Niazi Asfandyar K, Lavie Carl J, O'Keefe James H, Ventura Hector O
Wegmans Pharmacy, Ithaca, NY 14850, USA.
Congest Heart Fail. 2013 Jul-Aug;19(4):214-22. doi: 10.1111/chf.12037.
A systematic review of the literature was performed by searching Pubmed and EMBASE databases using the terms "thiamine," "vitamin B1," "heart failure," "systolic dysfunction," "ventricular dysfunction," "cardiomyopathy," "ventricular failure," and "systolic failure." Relevant trials and articles were evaluated pertaining to thiamine deficiency in patients with heart failure (HF) and references were searched for further inclusion of articles. A total of 20 articles were reviewed and summarized in detail. While more research is needed to fully elucidate the clinical thiamine deficiency in HF patients, recent evidence has indicated that supplementing with thiamine in HF patients has the potential to improve left ventricular ejection fraction. Thiamine deficiency appears to be not uncommon in patients with HF, and supplementation with thiamine has been shown to improve cardiac function, urine output, weight loss, and signs and symptoms of HF. Therefore, this simple therapy should be tested in large-scale randomized clinical trial to further determine the effects of thiamine in HF patients.
通过使用“硫胺素”“维生素B1”“心力衰竭”“收缩功能障碍”“心室功能障碍”“心肌病”“心室衰竭”和“收缩期衰竭”等术语检索PubMed和EMBASE数据库，对文献进行了系统综述。评估了与心力衰竭（HF）患者硫胺素缺乏相关的试验和文章，并搜索参考文献以进一步纳入文章。共详细审查和总结了20篇文章。虽然需要更多研究来充分阐明HF患者临床硫胺素缺乏情况，但最近的证据表明，HF患者补充硫胺素有可能改善左心室射血分数。硫胺素缺乏在HF患者中似乎并不罕见，补充硫胺素已被证明可改善心脏功能、尿量、体重减轻以及HF的体征和症状。因此，这种简单的治疗方法应在大规模随机临床试验中进行测试，以进一步确定硫胺素对HF患者的影响。
