Unité de Bioénergétique et Ingénierie des Protéines, Institut de Microbiologie de la Méditerranée, Centre National de la Recherche Scientifique and Aix-Marseille Université, France.
FEBS J. 2014 Jan;281(2):621-32. doi: 10.1111/febs.12469. Epub 2013 Sep 2.
The paper that introduced biochemists to the idea of allosteric feedback inhibition [Monod J, Changeux J-P & Jacob F (1963) J Mol Biol 6, 306-329] is now 50 years old, and the two papers on models for enzyme cooperativity that followed it [Monod J, Wyman J & Changeux J-P (1965) J Mol Biol 12, 88-118; Koshland DE, Némethy G & Filmer D (1966) Biochemistry 5, 365-385] are almost as old. All of these papers continue to be heavily cited today - more in the 21st century than they were in the last two decades of the 20th. This is because they continue to be central for understanding enzyme regulation, and increasingly important in the age of systems biology.
这篇介绍变构反馈抑制概念的论文发表于 50 年前[Monod J, Changeux J-P & Jacob F (1963) J Mol Biol 6, 306-329]，紧随其后的两篇关于酶协同作用模型的论文[Monod J, Wyman J & Changeux J-P (1965) J Mol Biol 12, 88-118; Koshland DE, Némethy G & Filmer D (1966) Biochemistry 5, 365-385]也有将近 50 年的历史了。时至今日，这些论文仍被大量引用——21 世纪的引用量比 20 世纪最后 20 年还要多。这是因为它们对于理解酶的调控仍然至关重要，并且在系统生物学时代变得越来越重要。
