State Key Lab of Analytical Chemistry for Life Science, and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
ACS Appl Mater Interfaces. 2013 Aug 28;5(16):8210-6. doi: 10.1021/am402328t. Epub 2013 Aug 19.
In this Article, we present a facile microwave-assisted synthesis route for the preparation of water-soluble and high-quality CuInS2/ZnS nanocrystals (NCs) with glutathione as the stabilizer. The as-prepared CuInS2/ZnS NCs exhibited small particle sizes (~3.3 nm), long photoluminescence lifetimes, and color-tunable properties ranging from the visible to the near-infrared by varying the initial ratio of Cu/In in the precursors. The low-toxicity, highly luminescent and biocompatible CuInS2/ZnS NCs were applied to cell imaging, showing that they could be used as promising fluorescent probes. Furthermore, the CuInS2/ZnS NCs were used as the signal labels for a fluoroimmunoassay of the biomarker IL-6, showing their great potential for use as reliable point-of-care diagnostics for biomarkers of cancer and other diseases.
在本文中，我们提出了一种简便的微波辅助合成路线，用于制备以谷胱甘肽为稳定剂的水溶性和高质量的 CuInS2/ZnS 纳米晶体（NCs）。所制备的 CuInS2/ZnS NCs 具有较小的粒径（约 3.3nm）、长的光致发光寿命以及通过改变前驱体中 Cu/In 的初始比例从可见到近红外可调的颜色。低毒性、高发光和生物相容性的 CuInS2/ZnS NCs 被应用于细胞成像，表明它们可用作有前途的荧光探针。此外，CuInS2/ZnS NCs 被用作生物标志物 IL-6 的荧光免疫分析的信号标记物，表明它们在用于癌症和其他疾病的生物标志物的可靠即时诊断方面具有很大的潜力。
