用于聚二甲基硅氧烷定量分析的核磁共振和红外光谱方法的比较。

Comparison of the nuclear magnetic resonance and infrared spectroscopic methods for the quantitative analysis of polydimethylsiloxane.

作者信息

O'Neill I K, Pringuer M A, Prosser H J

出版信息

J Pharm Pharmacol. 1975 Apr;27(4):222-5. doi: 10.1111/j.2042-7158.1975.tb10690.x.

DOI:10.1111/j.2042-7158.1975.tb10690.x

Abstract

A method based on nuclear magnetic resonance spectroscopy is described for the quantitative determination of polyimethylsiloxane (PMS) in a variety of pharmaceutical preparations. An extraction procedure using deuterochloroform within the sample tube was devised. In the presence of an internal standard, the PMS concentration was determined directly using integrated peak areas, without the necessity of establishing calibration curves. Accurate quantitative results were achieved with sample, containing at least 2mg PMS, extracted from formulations containing greater than 0.5% PMS. The extraction procedure and nmr assay were both more efficient and convenient than the B.P.C. method.

摘要

描述了一种基于核磁共振光谱法的方法，用于定量测定多种药物制剂中的聚二甲基硅氧烷（PMS）。设计了一种在样品管内使用氘代氯仿的萃取程序。在有内标物存在的情况下，直接使用积分峰面积来测定PMS浓度，无需建立校准曲线。从含PMS大于0.5%的制剂中提取的、至少含2mg PMS的样品，获得了准确的定量结果。萃取程序和核磁共振分析比英国药典方法更高效、更便捷。