Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, School of Mathematics, and Institute for Life Sciences, University of Southampton, SO17 1BJ, UK.
Cell. 2013 Aug 1;154(3):484-9. doi: 10.1016/j.cell.2013.07.024.
Recent reports using single-cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single-cell level but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory.
最近使用单细胞分析的报告表明，多能干细胞的特性具有显著的动态性。在这里，我们认为多能状态在单细胞水平上没有很好的定义，而是干细胞群体的统计特性，可以使用统计力学和信息论的工具进行分析。
