多能性的统计力学。
Statistical mechanics of pluripotency.
机构信息
Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, School of Mathematics, and Institute for Life Sciences, University of Southampton, SO17 1BJ, UK.
出版信息
Cell. 2013 Aug 1;154(3):484-9. doi: 10.1016/j.cell.2013.07.024.
PMID:23911316
Abstract
Recent reports using single-cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single-cell level but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory.
摘要
最近使用单细胞分析的报告表明，多能干细胞的特性具有显著的动态性。在这里，我们认为多能状态在单细胞水平上没有很好的定义，而是干细胞群体的统计特性，可以使用统计力学和信息论的工具进行分析。
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