Institute of Psychology, University of Greifswald, 17487 Greifswald, Germany.
J Anxiety Disord. 2013 Jun;27(5):485-93. doi: 10.1016/j.janxdis.2013.06.008. Epub 2013 Jul 10.
Full-blown panic attacks are frequently associated with other mental disorders. Most comorbidity analyses did not discriminate between isolated panic attacks vs. panic attacks that occurred in the context of a panic disorder and rarely evaluated the impact of comorbid agoraphobia. Moreover, there are no larger scale epidemiological studies regarding the influence of sub-threshold panic attacks. 4075 German-speaking respondents aged 18-64 were interviewed using the fully structured Munich Composite International Diagnostic Interview. Limited symptom attacks, isolated panic attacks, and panic disorder were associated with other lifetime DSM-IV disorders with monotonically increasing odds and increasing tendency for multiple comorbidities across the three groups. The presence of agoraphobia was associated with more frequent comorbidity in all panic subgroups and also in persons who never experienced panic attacks. The present study suggests that populations with isolated or limited symptom should be carefully attended to in clinical practice, especially if agoraphobia is present.
全面性恐慌发作常与其他精神障碍相关。大多数合并症分析并未区分孤立性恐慌发作与恐慌症发作，且很少评估合并性广场恐惧症的影响。此外，针对亚阈值恐慌发作的影响，尚无更大规模的流行病学研究。采用完全结构化的慕尼黑综合国际诊断访谈，对 4075 名年龄在 18-64 岁的德语应答者进行了访谈。有限症状发作、孤立性恐慌发作和恐慌症与其他终生 DSM-IV 障碍相关，其出现的可能性呈单调递增，且在三组人群中，多种合并症的趋势呈递增。广场恐惧症的存在与所有恐慌亚组以及从未经历过恐慌发作的人群中更频繁的合并症相关。本研究表明，在临床实践中应仔细关注孤立或有限症状的人群，特别是如果存在广场恐惧症。
