Kini U, Nirmala V, Thomas J A
Department of Pathology, St. John's Medical College, Bangalore, India.
Indian J Pathol Microbiol. 1990 Apr;33(2):137-43.
The purpose of this study has been to determine the prevalence of intestinal metaplasia (IM) and its subtypes in normal, benign and malignant states, with special reference to the significance of presence as well as location of sulphomucins in the metaplastic epithelium. Sixty-seven specimens of the normal, benign chronic gastric disease and gastric carcinoma have been studied. The overall prevalence of IM in gastric carcinoma has been found to be much higher (67 percent) than in the normal (nil) and benign lesions of stomach (11 percent). The sulphomucins producing IM also has a higher prevalence in gastric carcinoma (70 percent) but can occur in benign conditions also (40 percent). On the other hand Type III IM, characterized by sulphomucins in the columnar cells is seen only in gastric carcinoma, and not in the benign lesions.
本研究的目的是确定肠化生（IM）及其亚型在正常、良性和恶性状态下的患病率，特别提及化生上皮中硫黏液素的存在及位置的意义。已对67份正常、良性慢性胃病和胃癌标本进行了研究。已发现胃癌中IM的总体患病率（67%）远高于正常胃（无）和胃良性病变（11%）。产生硫黏液素的IM在胃癌中的患病率也较高（70%），但在良性情况下也可出现（40%）。另一方面，以柱状细胞中存在硫黏液素为特征的III型IM仅见于胃癌，而不见于良性病变。
