Jiang Y Q, Du X X, Guo S Y, Ma Z
Department of Pathology, Shanghai Second Medical University.
Chin Med J (Engl). 1990 Oct;103(10):821-5.
This article sums up the histochemical and immunohistochemical study of 55 cases of gastric carcinoma and 21 controls with benign gastric lesions. The results showed most of the adjacent mucosa of gastric carcinoma developed incomplete type intestinal metaplasia (IM). The percentage of Type IIb (ie, secreting sulphomucin) reached 72.5%. In most cases, high iron diamine (HID) rose in cancerous tissue and concomitantly in the IM epithelium of the adjacent gastric carcinoma. The phenomena of separation condition of HID+ in cancerous tissue, HID- in IM epithelium surrounding carcinoma, or HID- in cancerous cell but HID+ in IM of the surrounding epithelium of carcinoma, were much fewer. The two kinds of mucin antigen distribution were observed simultaneously. In the control and gastric carcinoma groups, neither large intestinal mucin antigen (LIMA) nor small intestinal mucin antigen (SIMA) could be detected in the normal epithelium of gastric mucosa. SIMA was mainly found in the goblet cells of IM and the mucous cells of columnar epithelium, while LIMA was mainly present in the columnar cells, in luminal border and/or in goblet cells. LIMA in the carcinoma group is apparently higher than that in the controls. The percentage of LIMA+ in the IM epithelium of adjacent gastric carcinoma and that in carcinoma cells were also raised in most cases. All these demonstrated a close relationship between IM and gastric carcinoma. Our results also showed that not only HID+, but also LIMA+ may represent a precancerous lesion in gastric carcinoma.
本文总结了55例胃癌及21例良性胃病变对照的组织化学和免疫组织化学研究。结果显示，大多数胃癌的邻近黏膜发生不完全型肠化生（IM）。IIb型（即分泌硫酸黏液素）的比例达到72.5%。在大多数情况下，高铁二胺（HID）在癌组织以及相邻胃癌的IM上皮中同时升高。癌组织中HID+、癌周IM上皮中HID-，或癌细胞中HID-但癌周上皮IM中HID+的分离情况现象较少。同时观察了两种黏蛋白抗原的分布。在对照组和胃癌组中，胃黏膜正常上皮中均未检测到大肠黏蛋白抗原（LIMA）和小肠黏蛋白抗原（SIMA）。SIMA主要见于IM的杯状细胞和柱状上皮的黏液细胞，而LIMA主要存在于柱状细胞、腔缘和/或杯状细胞中。癌组中的LIMA明显高于对照组。大多数情况下，相邻胃癌IM上皮和癌细胞中LIMA+的比例也升高。所有这些都表明IM与胃癌之间存在密切关系。我们的结果还表明，不仅HID+，而且LIMA+可能代表胃癌的癌前病变。
