过敏反应后豚鼠肺脂质含量变化的研究。

Investigation of changes in the lipid content of guinea-pig lung after anaphylaxis.

作者信息

Goadby P

出版信息

J Pharm Pharmacol. 1975 Apr;27(4):248-53. doi: 10.1111/j.2042-7158.1975.tb10694.x.

DOI:10.1111/j.2042-7158.1975.tb10694.x

Abstract

A detailed analysis of the lipid content of guinea-pig lung following anaphylaxis in vivo induced by aerosolized antigen showed a significant reduction in all fractions. Anoxia induced by nitrogen produced reductions in the partial glycerides and ethanolamine phospholipid. Exposure to an aerosol of histamine caused a reduction in all but the choline phospholipid and sphingolipid fractions. It was concluded that the losses of choline phospholipid and sphingolipid result from the anaphylactic reaction and not from subsequent changes.

摘要

对雾化抗原在体内诱发过敏反应后的豚鼠肺脂质含量进行的详细分析表明，所有组分均显著减少。氮气诱导的缺氧导致甘油二酯和乙醇胺磷脂减少。暴露于组胺气雾剂中会使除胆碱磷脂和鞘脂组分之外的所有组分减少。得出的结论是，胆碱磷脂和鞘脂的损失是由过敏反应导致的，而非后续变化所致。

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