Liang Yingkai, Kiick Kristi L
Department of Materials Science and Engineering, 201 DuPont Hall, University of Delaware, Newark, DE 19716, USA.
Department of Materials Science and Engineering, 201 DuPont Hall, University of Delaware, Newark, DE 19716, USA; Biomedical Engineering, University of Delaware, Newark, DE 19716, USA; Delaware Biotechnology Institute, 15 Innovation Way, University of Delaware, Newark, DE 19711, USA.
Acta Biomater. 2014 Apr;10(4):1588-600. doi: 10.1016/j.actbio.2013.07.031. Epub 2013 Aug 2.
Heparin plays an important role in many biological processes via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties, such as anticoagulant activity, growth factor binding, and antiangiogenic and apoptotic effects, making them great candidates for emerging applications. Accordingly, this review summarizes recent efforts in the preparation of heparin-based hydrogels and formation of nanoparticles, as well as the characterization of their properties and applications. The challenges and future perspectives for heparin-based materials are also discussed. Prospects are promising for heparin-containing polymeric biomaterials in diverse applications ranging from cell carriers for promoting cell differentiation to nanoparticle therapeutics for cancer treatment.
肝素通过与各种蛋白质相互作用在许多生物过程中发挥重要作用，包含肝素的水凝胶和纳米颗粒具有诸如抗凝活性、生长因子结合以及抗血管生成和凋亡作用等吸引人的特性，使其成为新兴应用的理想候选者。因此，本综述总结了近期在制备基于肝素的水凝胶、形成纳米颗粒以及表征其性质和应用方面所做的努力。还讨论了基于肝素的材料面临的挑战和未来前景。含肝素的聚合物生物材料在从促进细胞分化的细胞载体到癌症治疗的纳米颗粒疗法等各种应用中的前景十分广阔。
