Qin Hongwei, Li Ze, Li Sicheng, Huang Jinjian, Ren Jianan, Wu Xiuwen
The First Hospital of AUST, Anhui University of Science and Technology, Huainan, China.
Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, China.
J Tissue Eng. 2025 Jun 25;16:20417314251342175. doi: 10.1177/20417314251342175. eCollection 2025 Jan-Dec.
Inflammatory cytokines play a crucial role in the inflammatory response, and their aberrant expression and overproduction are closely associated with the development of many diseases. However, traditional inflammation treatment strategies are often accompanied by serious side effects, limiting their widespread use. In recent years, hydrogel, as a material with a three-dimensional network structure, good biocompatibility and modulability, has great potential for trapping and neutralizing inflammatory factors. Hydrogels can capture and neutralize inflammatory cytokines through various mechanisms such as electrostatic interactions, coupling with cytokine antibodies or binding nanoparticles. In addition, hydrogel microspheres, an important form of hydrogels, have excellent broad-spectrum binding of inflammatory cytokines in combination schemes with cell membranes. This article reviews recent research advances in hydrogel capture and neutralization of inflammatory cytokines, discussing the advantages of various mechanisms and their applications in different diseases. Overall, we believe that hydrogels are expected to further advance the development of therapeutic modalities for inflammatory diseases in the future.
炎性细胞因子在炎症反应中起关键作用，其异常表达和过度产生与许多疾病的发展密切相关。然而，传统的炎症治疗策略往往伴随着严重的副作用，限制了它们的广泛应用。近年来，水凝胶作为一种具有三维网络结构、良好生物相容性和可调节性的材料，在捕获和中和炎症因子方面具有巨大潜力。水凝胶可以通过静电相互作用、与细胞因子抗体偶联或结合纳米颗粒等多种机制捕获和中和炎性细胞因子。此外，水凝胶微球作为水凝胶的一种重要形式，在与细胞膜的组合方案中对炎性细胞因子具有优异的广谱结合能力。本文综述了水凝胶捕获和中和炎性细胞因子的最新研究进展，讨论了各种机制的优势及其在不同疾病中的应用。总体而言，我们认为水凝胶有望在未来进一步推动炎症性疾病治疗方式的发展。
