Tomoda Takeshi, Ueki Toru, Saito Shunsuke, Tatsukawa Masashi, Nawa Toru, Hamamoto Hiromi, Endo Hisashi, Yabushita Kazuhisa, Shimoe Toshinari, Sakaguchi Kosaku
Department of Internal Medicine, Fukuyama City Hospital, Japan.
Nihon Shokakibyo Gakkai Zasshi. 2013 Aug;110(8):1481-6.
We report a case of a 47-year-old female patient with ceftriaxone (CTRX)-associated pseudolithiasis. CTRX was administered at a dosage of 2g/day for 8 days because of colonic diverticulitis. A routine abdominal computed tomography (CT) scan was performed to investigate the diverticulitis. However, the CT scan demonstrated stones and sludge in the gallbladder, which had not been present before CTRX administration. Therefore, we diagnosed the patient with pseudolithiasis caused by CTRX and stopped CTRX administration. The stones and sludge disappeared 6 days after stopping CTRX administration. This underreported adverse effect of CTRX should be considered when treating both children and adult patients.
我们报告一例47岁女性患者发生头孢曲松(CTRX)相关性假性结石症。该患者因结肠憩室炎接受CTRX治疗,剂量为每日2g,共8天。为检查憩室炎进行了常规腹部计算机断层扫描(CT)。然而,CT扫描显示胆囊内有结石和胆泥,而在使用CTRX之前并未出现。因此,我们诊断该患者为CTRX所致的假性结石症,并停用了CTRX。停用CTRX 6天后,结石和胆泥消失。在治疗儿童和成年患者时,均应考虑CTRX这种报告较少的不良反应。