Departments of Diabetes, Metabolism and Endocrinology, Japan Labor Health and Safety Organization, Tokyo Rosai Hospital, Japan.
Intern Med. 2023 Nov 15;62(22):3367-3371. doi: 10.2169/internalmedicine.1405-22. Epub 2023 Apr 7.
Biliary pseudolithiasis is a ceftriaxone (CTRX)-induced complication, but the risk in cases of elderly type 1 diabetes mellitus (T1DM) is unclear. Case 1: A 78-year-old woman with T1DM complicated by diabetic autonomic neuropathy was admitted with pneumonia and treated with CTRX. On day 8, biliary pseudolithiasis and cholecystitis were observed. Case 2: an 80-year-old woman with T1DM was suspected of having a urinary tract infection and treated with CTRX. After a week, she developed asymptomatic biliary pseudolithiasis with gastroparesis. CTRX-associated biliary pseudolithiasis was thus noted in these cases of elderly T1DM. CTRX should be cautiously administered, especially in elderly T1DM patients with diabetic autonomic neuropathy.
胆道假性结石症是一种头孢曲松（CTRX）诱导的并发症，但在老年 1 型糖尿病（T1DM）病例中的风险尚不清楚。
病例 1：一名 78 岁女性患有 T1DM 合并糖尿病自主神经病变，因肺炎入院并接受 CTRX 治疗。第 8 天，观察到胆道假性结石和胆囊炎。
病例 2：一名 80 岁女性患有 T1DM，怀疑患有尿路感染并接受 CTRX 治疗。一周后，她出现无症状胆道假性结石症伴胃轻瘫。因此，这两例老年 T1DM 患者均诊断为 CTRX 相关性胆道假性结石症。在老年 T1DM 患者，尤其是合并糖尿病自主神经病变的患者中，应谨慎使用 CTRX。
