Department of Pharmaceutical Sciences, College of Pharmacy University of Kentucky, Lexington, Kentucky, USA.
Nat Chem Biol. 2013 Oct;9(10):602-3. doi: 10.1038/nchembio.1319. Epub 2013 Aug 4.
Biological sulfonate incorporation is mediated by 3′-phosphoadenosine-5′-phosphosulfate-dependent sulfotransferases and, to a lesser extent, arylsulfate sulfotransferases. An unusual two-enzyme strategy for sulfonate mobilization involving both types of sulfotransferases has been revealed during antibiotic biosynthesis, which uses a new polyketide as the sulfonate shuttle.
生物磺酸盐的掺入是由 3′-磷酸腺苷-5′-磷酸磺酸盐依赖的磺基转移酶介导的，在较小程度上也由芳基硫酸盐磺基转移酶介导。在抗生素生物合成过程中，揭示了一种涉及两种磺基转移酶的磺酸盐动员的不寻常的双酶策略，该策略使用新的聚酮体作为磺酸盐穿梭体。
