Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Phys Med Biol. 2013 Aug 21;58(16):5783-801. doi: 10.1088/0031-9155/58/16/5783. Epub 2013 Aug 2.
An optimal experiment design methodology was developed to select the framing schedule to be used in dynamic positron emission tomography (PET) for estimation of myocardial blood flow using (82)Rb. A compartment model and an arterial input function based on measured data were used to calculate a D-optimality criterion for a wide range of candidate framing schedules. To validate the optimality calculation, noisy time-activity curves were simulated, from which parameter values were estimated using an efficient and robust decomposition of the estimation problem. D-optimized schedules improved estimate precision compared to non-optimized schedules, including previously published schedules. To assess robustness, a range of physiologic conditions were simulated. Schedules that were optimal for one condition were nearly-optimal for others. The effect of infusion duration was investigated. Optimality was better for shorter than for longer tracer infusion durations, with the optimal schedule for the shortest infusion duration being nearly optimal for other durations. Together this suggests that a framing schedule optimized for one set of conditions will also work well for others and it is not necessary to use different schedules for different infusion durations or for rest and stress studies. The method for optimizing schedules is general and could be applied in other dynamic PET imaging studies.
一种优化实验设计方法被开发出来，用于选择在动态正电子发射断层扫描（PET）中使用的帧方案，以使用（82）Rb 估计心肌血流。使用基于测量数据的室模型和动脉输入函数来计算广泛候选帧方案的 D 最优性标准。为了验证最优性计算，模拟了噪声时间-活性曲线，从这些曲线中使用估计问题的有效和鲁棒分解来估计参数值。与非最优方案相比，D 最优方案可提高估计精度，包括以前发表的方案。为了评估稳健性，模拟了一系列生理条件。对于一种情况是最优的方案，对于其他情况也是近乎最优的。还研究了输注持续时间的影响。对于较短的示踪剂输注持续时间，最优性更好，对于最短输注持续时间的最优方案对于其他持续时间也几乎是最优的。这表明，为一组条件优化的帧方案也将在其他条件下很好地工作，并且对于不同的输注持续时间或对于休息和应激研究，不需要使用不同的方案。优化方案的方法是通用的，可以应用于其他动态 PET 成像研究。
